Ferritin





Ferritin (FR) is an iron storage and release protein. It stores iron as microcrystals with phosphate and hydroxide ions. FR is composed of 24 subunits of heavy chain (FTH) and light chain (FTL). Bacterioferritin (BFR) structure is very similar to FR. It contains a binuclear iron center and haem. It stores iron as ferric oxide mineral in its hollow central cavity. Thioferritin (TFR) is a ferritin-related protein with 2 cysteine residues adjacent to the dimetal binding site. Another iron storing protein is the DNA-binding Protein of Starved cells (Dps). MrgA – another iron storage protein - belongs to the Dps family.

3D Structures of Ferritin
Update June 2011

Ferritin
2jd6, 2jd7 – PfFR - Pyrococcus furiosus

2jd8 – PfFR+Zn

3kxu – hFR (mutant) – human

3hx2, 3hx5, 3hx7, 1fha - hFR

3a68 – soFR from gene SferH4 – soybean

3a9q - soFR from gene SferH4 (mutant)

3egm, 3bvf, 3bvi, 3bvk, 3bvl – HpFR – Heliobacter pylori

3e6s - PnFR – Pseudo-nitzschia

1z4a, 1vlg – FR – Thermotoga maritime

1s3q, 1sq3, 3kx9 – FR – Archaeoglubus fulgidus

1krq – FR – Campylobacter jejuni

1eum - EcFR – Escherichia coli

1qgh – LiFR - Listeria innocua

1mfr, 1bg7, 3ka3, 3ka4 – bFR - Bullfrog

3ka6, 3ka8, 3ka9 – bFR (mutant)+Co

Ferritin light chain (FTL)
1lb3, 1h96 – FTL – mouse

1rcc, 1rcd, 1rci – bFTL+tartrate+Mg

1rce, 1rcg - bFTL+tartrate+Mn

3noz, 3np0, 3np2 – hoFTL (mutant) - horse

3rav, 3rd0 – hoFTL + barbiturate

Ferritin heavy chain (FTH)
2z6m, 1r03, 2fha, 3ajo – hFTH

3ajp, 3ajq - hFTH (mutant)

2z6o – FTH – Trichoplusia ni

apo-ferritin (apo-FR)
2x17 – apo-PfFR+Ag

3h7g – apo-hoFR+Au

1hrs - apo-hoFR+protoporphyrin

3bve – apo-HpFR

3e6r – apo-PnFR

2clu, 2cn6 - apo-hFR (mutant)+Zn

apo-ferritin light chain (apo-FTL)
2zg7, 2z5p, 2z5q, 2z5r, 3fi6, 3af7 – apo-hoFTL+Pd

2zg8, 2zg9, 3af8, 3af9 - apo-hoFTL (mutant)+Pd

3f33, 3f34, 3f35, 3f36, 3f37, 3f38, 3f39 - apo-hoFTL+phenols

2v2i, 2v2j - apo-hoFTL+haemin

2gyd - apo-hoFTL+diaziflurane

1xz1 - apo-hoFTL+halothane

1xz3 - apo-hoFTL+isoflurane

1gwg - apo-hoFTL+I3

2v2l, 2v2m, 2v2n, 2v2o, 2v2p, 2v2r, 2v2s - apo-hoFTL (mutant)+haemin

2za6, 2g4h, 1aew, 1dat, 1ier, 1ies, 3f32, 2zur, 2w0o - apo-hoFTL

2ffx, 2fg4, 2fg8 – apo-hFTL

apo-ferritin heavy chain (apo-FTH)
2za7, 2za8, 2cn7, 2chi, 2clu - apo-hoFTH (mutant)

2cei, 2cih, 2cn6, 2iu2 - apo-hoFTH (mutant)+Zn

3erz – apo-hFR+Hg

3es3 - apo-hFR+Au

Bacterioferritin (BFR)
3gvy – BFR – Rhodobacter sphaeroides

1jgc - BFR – Rhodobacter capsulatus

1ji4 – BFR – Helicobacter pylori

1nf4, 1nf6, 1nfv – BFR – Desulfovibrio desulfuricans

3fvb – BmBFR - Brucelia melitensis

2fkz, 2fl0, 1sof – BFR – Azotobacrter vinelandii

2wtl – BFR – Mycobacterium tuberculosis

3bkn - BFR – Mycobacterium smegmatis

3is7, 3is8, 3ise, 3isf, 3r2h, 3r2k, 3r2l, 3r2m, 3r2o, 3r2r, 3r2s – BFR – Pseudomonas aeruginosa

1bfr, 1bcf, 2htn, 2vxi, 3e1j, 3e1l, 3e1m, 3e1n, 3e1p, 3e1o, 3e1q, 2y3q – EcBFR

3e2c, 3ghq – EcBFR (mutant)

Thioferritin (TFR)
2vzb – TFR – Bacterioides fragilis

DNA-binding Protein of Starved cells (Dps)
3iq1 – Dps – Vibrio cholerae

3ge4 – BmDps

2iy4 – Dps – Listeria monocytogenes

2bkc, 2bk6, 2bjy – LiDps (mutant)

2f7n – Dps – Deinococcus radiodurans

1tjo, 1tk6, 1tkp, 1tko, 1moj – Dps – Halobacterium salinarum

1o9r – Dps – Agrobacterium tumefaciens

1dps – EcDps

MrgA
2chp – MrgA – Bacillus subtilis